Perineural Invasion in Head and Neck Cancer
نویسندگان
چکیده
منابع مشابه
Perineural invasion in head and neck cancers - a review-
RATIONALE perineural invasion is an under-recognized way of metastatic spread via tumoral invasion of the nerves. It is encountered in malignancies located in the head and neck but also in cancers involving the pancreas, colon and rectum, prostate, biliary tract and stomach. For some tumors, it may be the only way of metastatic spread. It represents a marker for poor outcome, with increased ris...
متن کاملGalanin modulates the neural niche to favour perineural invasion in head and neck cancer
Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately, there is no targeted treatment for PNI since the molecular mechanisms are largely unknown. PNI is an active process, suggesting that cancer cells communicate with nerves. However, nerve-tumour crosstalk is understudied due to the lack of in vivo models to investigate the mechanisms. Here we developed ...
متن کاملPerineural invasion of head and neck skin cancer: diagnostic and therapeutic implications.
Perineural invasion of head and neck skin cancer is a poorly understood and often misdiagnosed pathological entity. Incidental or microscopic perineural invasion is identified by the pathologist and often leads to confusion as to how the patient should be further treated. The less common but more aggressive clinical perineural spread presents with a clinical deficit, which is too commonly misin...
متن کاملImaging of perineural tumor spread in head and neck cancer.
Perineural spread (PNS) of head and neck tumors is a well-described phenomenon whereby a lesion can migrate away from the primary site along the neural sheath. By this mechanism, tumor can spread a considerable distance and compromise vital neurologic structures, with significant impact on treatment and prognosis. It is crucial that radiologists search for PNS whenever imaging the head and neck...
متن کاملPerineural Spread in Head and Neck Cancer: Current Perspectives
Perineural spread is mechanism of tumor dissemination along a nerve in the head and neck with decreased survival and a higher risk of local recurrence and metastasis. Even though several theories have been proposed, pathogenesis of perineural spread is poorly understood. Advances in diagnostic imaging and the development of new fronts like skull base surgery have brought a transcending change i...
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ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2018
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034518756297